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Contents • • • • • • Function [ ] This gene is a putative encoding a protein belonging to the subfamily of that contain -like (Src homology 2-like) domains. The encoded protein is a general protein kinase capable of phosphorylating several known proteins.

Clinical significance [ ] The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary. Overexpression contributes to the malignant phenotype of a subset of human ductal. Mice lacking Akt2 have a normal body mass, but display a profound diabetic phenotype, indicating that Akt2 plays a key role in downstream of the. Mice lacking Akt2 show worse outcome in initiated by the as well as the. Interactions [ ] AKT2 has been shown to with.